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KMID : 0988920100080010075
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Intestinal Research
2010 Volume.8 No. 1 p.75 ~ p.79
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Postradiation Malignant Fibrous Histiocytoma of the Colon: A Case Report
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Yoon Jin-Young
Cheon Jae-Hee
Park Jae-Jun
Kim Tae-Il
Kim Won-Ho
Kim Nam-Kyu
Shin Sang-Hoon
Moon Chang-Mo
Lee Chan-Joo
Kim Eun-Young
Jung Ju-Won
Kim Ho-Keun
Kim Do-Kyung
Park Eun-Young
Kim Tae-Hoon
Hong Sung-Pil
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Abstract
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Post-radiation soft tissue sarcomas are recognized as rare complications of radiation therapy. The most common type of post-radiation soft tissue sarcoma is a malignant fibrous histiocytoma (MFH), which originates from mesenchymal cells with a predominance of histiocytes and fibroblasts. The two most common sites of occurrence for post-radiation soft tissue sarcomas are the chest wall and pelvic cavity. Post-radiation colorectal MFHs are extremely rare and all of the reported cases of post-radiation sarcomas have occurred ＞3 years after radiation therapy. Recently, we managed a case of colorectal MFH which developed in a 48-year-old male who had undergone a low anterior resection for rectal adenocarcinoma and had received chemoradiotherapy as adjuvant treatment. Twelve months after radiotherapy, a 4 cm mass was detected 8 cm superior to the anastomosis site on colonoscopic examination. A soft tissue sarcoma was suspected on pathologic examination of the biopsy specimen. Therefore, he underwent a Hartmann’s operation and the final pathologic finding revealed MFH with a storiform pattern of tumor cells composed of pleomorphic, multinucleated giant cells. This is the first case of MFH that had a latency period ＜3 years (i.e., 1 year) between the time of radiotherapy and diagnosis.
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KEYWORD
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Neoplasm, Radiation Induced, Histiocytoma, Malignant Fibrous, Sarcoma
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